Name | 4-iodobenzyl bromide |
Synonyms | IR D1E 16004-15-2 p-odobenzyl bromide 4-IODOBENZYL BROMIDE P-IODOBENZYL BROMIDE 4-iodobenzyl bromide à-bromo-4-iodotoluene ALPHA-BROMO-4-IODOTOLUENE alpha-Bromo-4-iodotoluene 1-(Brommethyl)-4-iodbenzol 1-BROMOMETHYL-4-IODO-BENZENE 1-(Bromomethyl)-4-iodobenzene Benzene, 1-(bromomethyl)-4-iodo- 4-Iodobenzyl Bromide p-Iodobenzyl Bromide |
CAS | 16004-15-2 |
InChI | InChI=1/C7H6BrI/c8-5-6-1-3-7(9)4-2-6/h1-4H,5H2 |
InChIKey | BQTRMYJYYNQQGK-UHFFFAOYSA-N |
Molecular Formula | C7H6BrI |
Molar Mass | 296.93 |
Density | 2.0672 (rough estimate) |
Melting Point | 78-82°C(lit.) |
Boling Point | 140°C 15mm |
Flash Point | 140°C/15mm |
Water Solubility | Insoluble in water. |
Vapor Presure | 0.0202mmHg at 25°C |
Appearance | Adhering Crystalline Powder |
Color | Light yellow |
BRN | 2325160 |
Storage Condition | 2-8°C |
Sensitive | Light Sensitive/Lachrymatory |
Refractive Index | 1.6500 (estimate) |
Risk Codes | R34 - Causes burns R63 - Possible risk of harm to the unborn child R42/43 - May cause sensitization by inhalation and skin contact. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S23 - Do not breathe vapour. |
UN IDs | UN 3261 8/PG 2 |
WGK Germany | 3 |
HS Code | 29039990 |
Hazard Note | Corrosive/Lachrymatory/Light Sensitive |
Hazard Class | 8 |
Packing Group | Ⅱ |
Application | 4-iodobenzyl bromide is an organic intermediate, which can be obtained by bromination of 4-iodotoluene. It has been reported that it can be used to prepare isoxazolamide derivatives of artemisinin keto acid. |
prepare | add bromine (3.6ml,69.9mmol) and 30% hydrogen peroxide (5.2g,45.9mmol) water (70ml) solution to 4-iodotoluene (10.0g,45.9mmol) dichloromethane (70ml) solution sequentially at room temperature, heat the reaction solution, and stir vigorously under reflux for 10 hours (bath temperature: 50 ℃). Transfer the reaction solution to a separatory funnel, add chloroform (40ml) and water (20ml) to the funnel to delaminate, and wash the organic layer 3 times with water (150ml). In turn, the organic layer was washed with 0.5% sodium bisulfite aqueous solution (150ml) and water (150ml), and the solvent was removed under reduced pressure (bath temperature: 25 ℃). Before completely removing the solvent, add toluene (50ml) to the mixture, and then concentrate the mixture. This process is carried out twice. The mixture was concentrated to dry solid and the residue was dried under vacuum to prepare 4-iodobenzyl bromide (12.1g). |